Association between arsenic exposure and a measure of subclinical sensory neuropathy in Bangladesh

Publication Status is "Submitted" Or "In Press: 
LDEO Publication: 
Publication Type: 
Year of Publication: 
2005
Editor: 
Journal Title: 
Journal of Occupational and Environmental Medicine
Journal Date: 
Aug
Place Published: 
Tertiary Title: 
Volume: 
47
Issue: 
8
Pages: 
778-784
Section / Start page: 
Publisher: 
ISBN Number: 
1076-2752
ISSN Number: 
Edition: 
Short Title: 
Accession Number: 
ISI:000231153200003
LDEO Publication Number: 
Call Number: 
Abstract: 

Objectives: We examined the association between arsenic exposure and peripheral neuropathy in Bangladesh, where the population has been chronically exposed to arsenic in drinking water. Methods: We conducted a cross-sectional study of 137 subjects derived from a larger cohort. Exposure measures included individual water arsenic concentration, cumulative arsenic index, and urinary arsenic concentration taken at two time points (2001 and 2003). The primary outcome measurement was elevated vibrotactile threshold, as measured by a vibration sensitivity tester (Vibratron II). Results: Arsenic exposure. was associated with elevated toe vibration threshold (TVT). Specifically, cumulative arsenic index and urinary arsenic (2001) were both significantly associated with elevated TVT (P = 0.02 and P = 0.009, respectively) after adjustment for age and gender. Conclusions: Increased arsenic exposure, as measured by both cumulative and urinary measures, was associated with evidence of subclinical sensory neuropathy. .

Notes: 

954KETimes Cited:8Cited References Count:33

DOI: 
DOI 10.1097/01.jom.0000169089.54549.db